Chicago Health | Homepage
Do you know your personal colorectal cancer risk?

Do you know your personal colorectal cancer risk?

By Michael Kattan, Ph.D.

What is your risk of having colorectal cancer? If you are approaching or have passed your 50th birthday, your doctor probably has advised you to have colorectal cancer screening to determine that. And that’s the problem.

Since the late 20th century, this one-size-fits-all advice has been standard because there has been no other reliable way of predicting a specific individual’s risk of developing this deadly disease. That’s why our team at Cleveland Clinic’s Lerner Research Institute invented an online calculator to help physicians decide when patients truly need colorectal screenings.

The CRC-PRO, Colorectal Cancer Predicted Risk Online, allows physicians to quickly and accurately determine an individual patient’s likelihood of developing colorectal cancer.

Our team analyzed about a decade’s worth of data on more than 180,000 patients and identified strong links between certain risk factors and colorectal cancer.

We produced separate calculators for men and women. In addition, we took into account differences among racial groups, for which the risks differ dramatically.

This was important because, until now, research into colorectal cancer risk mainly focused on Caucasians. A calculator that accounts for multiple factors provides clinicians with a more accurate way of predicting risk than relying on a single risk factor, such as age.

Clinicians using this calculator can decide to screen high-risk patients before age 50, for instance, while delaying or forgoing screening in low-risk individuals, regardless of their age.

A safer approach can save lives

This approach is much safer for patients who might not need the procedure and can be lifesaving for younger patients who ordinarily would not have the screening until years later, when it might be too late.

Also important: Accurate prediction helps improve the efficiency of screening while lowering healthcare costs by reducing unnecessary testing. Our research results, which showed that the tool is accurate and user-friendly, were published in the Journal of the American Board of Family Medicine.

As someone who has had cancer — I received a Stage IV Hodgkin’s lymphoma diagnosis while I was beginning work on my doctorate — I have been driven to help find a better way of predicting cancer risk as well as outcomes. I’m also driven to use that information to develop a personalized prevention or management strategy.

I learned firsthand how inaccurate existing cancer staging systems were at the time of my diagnosis.

Why we need personalized cancer predictions

Staging systems are based on physical exams, imaging procedures, lab tests, and pathology and surgical reports that help doctors determine the cancer’s severity. I soon recognized the need to have personalized predictions through calculators. And I changed my career path from financial prediction to healthcare outcomes.

Developing risk prediction calculators like the CRC-PRO is vital for improving medical decision-making. Our research team is creating a number of such online tools for other diseases, including heart disease and cancers of the breast, prostate and thyroid.

We also are working on software to integrate these tools for automatic calculation in a patient’s electronic health record, making it even easier for physicians to devise an effective treatment plan.

(Michael Kattan, Ph.D., is the chair of the department of quantitative health sciences at Cleveland Clinic Lerner Research Institute. WhatDoctorsKnow is a magazine devoted to up-to-the minute information on health issues from physicians, major hospitals and clinics, universities and health care agencies across the U.S. Online at


Similar Articles

Speaking Up About Prostate Cancer

Speaking Up About Prostate Cancer

Above photo: Ken Griffey Sr. By Laura Drucker Ken Griffey Sr. had reason to be worried

Beyond Chemo

Beyond Chemo

Immunotherapy treatments rev up immune system to fight cancer By Katie Scarlett Brandt Six years ago Henry Kawell, then 72,

Count ingredients, not calories

Count ingredients, not calories

By Sharon Palmer, R.D.N. Shift your focus from the calories label to the ingredients label, and

Pneumonia a leading cause of hospitalization for children

Pneumonia a leading cause of hospitalization for children

What Doctors Know Source: U.S. Centers for Disease Control and Prevention Pneumonia puts thousands of young children

Getting Over It: Why You Should Get a Colonoscopy

Getting Over It: Why You Should Get a Colonoscopy

Facing the discomfort of a colonoscopy is a sure way to avoid the greater discomfort and

Articles By Category

Family Health

In The Know

CH Lifestyle

October 2016
Sunday Monday Tuesday Wednesday Thursday Friday Saturday
September 25, 2016 September 26, 2016 September 27, 2016 September 28, 2016 September 29, 2016 September 30, 2016 October 1, 2016
October 2, 2016 October 3, 2016 October 4, 2016 October 5, 2016 October 6, 2016 October 7, 2016 October 8, 2016
October 9, 2016 October 10, 2016 October 11, 2016 October 12, 2016 October 13, 2016 October 14, 2016 October 15, 2016
October 16, 2016 October 17, 2016 October 18, 2016 October 19, 2016 October 20, 2016 October 21, 2016 October 22, 2016
October 23, 2016 October 24, 2016 October 25, 2016 October 26, 2016 October 27, 2016 October 28, 2016 October 29, 2016
October 30, 2016 October 31, 2016 November 1, 2016 November 2, 2016 November 3, 2016 November 4, 2016 November 5, 2016


Recent Comments

Swing for the fences in the fight to Sideline Pancreatic Cancer

Swing for the fences in the fight to Sideline Pancreatic Cancer

Enjoy a great night of baseball at Peoples Natural

Cost to give birth 1943 - Page 3 - Defending The Truth Political Forum

Cost to give birth 1943 - Page 3 - Defending The Truth Political Forum

A Hazy Shade of Healthcare: What does tort reform